Sugarcane ethanol is considered to be one of the most efficient first-generation biofuels in terms of greenhouse gas (GHG) emis-sions. This case study investigates sugarcane ethanol production in the Republic of Malawi, in Sub-Sahara Africa (SSA). The currently high CF could be reduced when open storage of the vinasse, a liquid residue from fermentation, is discontinued. Another measure is to switch from pre-harvest burning to green harvesting so that the additionally available cane trash could be used as a fuel in the ethanol manufacturing.